Ctrl is reserved for force action. If you have let's say hydro blast on 1, then if you want to attack a player that's not purple, red, or in a clan you have a two sided war with, you have to use ctrl+1.
That said, if you use the enter chat option, then you can use the first skill bar with 0-9(0 uses the 10th slot), the second with f1-f12 and the third with the numpad (in case you have numeric key equvalents on your mouse or something), so you can use quite a bit of skills without having to click that way.