no m8 it will check for it , which mean if you place like 10 of item skills it will go through all 10 of item skills before it will again cast your main attack skill and thats additional delay to do so . If item skill are active and require to cast. Developers should do something out of this. just turn skill on so it apply to your character stats without any need of waste macro slots like at all! item skills should not consume my time to cast skills for damage.